Christina Applegate’s recent hospitalization comes during an especially difficult chapter of her life, as she continues speaking openly about living with multiple sclerosis.

She has shared honest details in interviews and in her memoir, describing numbness in her limbs, overwhelming exhaustion, and daily struggles that make even simple tasks feel exhausting.

Some mornings, even reaching for a glass of water can feel like a major challenge. She has compared the fatigue to the heavy effect of strong medication, showing how deeply the illness affects her routine.

Each new flare-up and unexpected emergency room visit makes the fight even harder, slowly threatening the independence she has worked so hard to maintain.